Apply for funding

How to apply for research funding for PSC research

Mission 2030

By 2030, we will fund and support more PSC research than ever before, offering over £1 million in grants to researchers to:

fund PSC studies aligned with our Research Strategy, turning researchers’ ideas into reality; and
fund 3-4 year PhD clinical fellowships in PSC to help develop the careers of future PSC specialists and to fill the critical gaps in our knowledge about PSC

Mission 2030 - find out more

Research we're funding

Apply for 2026 Funding

PSC Support welcomes grant applications for PSC-related research. As a member of the Association of Medical Research Charities, PSC Support employs strict peer review processes to ensure we fund only the highest quality research that advances our understanding of PSC and accelerates the development of effective tools, treatments, and care.

Note on Disease Scope: All applications must focus primarily on primary sclerosing cholangitis (PSC), recurrent PSC (rPSC), cholangiocarcinoma (CCA) with PSC, or inflammatory bowel disease with PSC (PSC-IBD).

How to Apply

We operate a two-stage application process for our research grant calls:

Stage 1: Letter of Intent (LOI)

Applicants must submit a concise Letter of Intent (LOI) via our online Grant Portal. LOIs undergo administrative triage to confirm eligibility, budget adherence, and fit with our strategic priorities.

LOI Call Opens: 01 Aug 2026
LOI Submission Deadline: 31 Aug 2026, 23:59 (BST)

Stage 2: Full Application (By Invitation Only)

Applicants whose LOIs pass initial triage will be invited to submit a full grant application. Full applications undergo rigorous peer review by independent scientific experts and patient reviewers, followed by assessment by our Scientific Review Committee.

Access our Grant Portal

Ready to start your submission? Click below to access our online application system. First-time users will need to register an account.

Access the PSC Support Grant Portal

Available Awards in 2026

Projects

£50,000

WORLDWIDE

Opens for letters of intent: 01/08/2026

More Information

Seed funding

£15,000

WORLDWIDE

Opens for letter of intent: 01/08/2026

More Information

Research Training Fellowships

£300,000 for up to three years when funds allow
UK-ONLY

Next Round TBC

Our Expert Review Process

We aim to complete this process in four to five months.

Find out more

Our Scientific Review Committee

Our Scientific Review Committee is independent of the charity's staff and trustees.

Dr Roger Chapman (Chair)
Dr Luke Boulter
Dr Emma Culver
Chris Forde (lay)
Iain M (lay)
Ed Sims (lay)
Professor Douglas Thorburn
Dr Andrew Yeoman

Scientific Review Committee Terms of Reference

Research Proposal Appraisals

For each funding application, expert reviewers (at least two scientific experts and two lay experts) will submit written reviews to the PSC Support Scientific Review Committee according to set criteria. The Trustees of PSC Support will approve or deny the awarding of a grant based upon the recommendations of the SRC. Applicants will be notified of this decision in Autumn.

External reviewers will be selected where the Committee does not have sufficient expertise, or where the grant is £55,000 and above. External reviewers may be selected from the wider research and clinical community, or be selected because they have special expertise related to a funding application. PSC Support will work with the Scientific Review Committee to identify appropriate external reviewers.

The Trustees of PSC Support have the final decision regarding funding research projects.

Grants are awarded on the basis of scientific merit and clear relevance to PSC Support’s Research Strategy. The Scientific Review Committee scores the application according to the following criteria:

Scientific Appraisal Criteria Guide

Relevance of idea or proposal
How the proposal relates to our charity aims and priorities.
Originality
Does the proposal address an important and valid research question? Also refer to PSC Unanswered Questions.
Realistic costing and value for money
Is the budget realistic, value for money and costs justified?
Relationship to and the volume of research already available in the field
Has the proposal considered relevant PSC literature and developments?
Scientific quality or methodology
What is the quality of the experimental design or method?
Expertise of researchers
Does the research team have the right expertise for the proposed research?
Use of animals in research
Funding applications involving the use of animals must comply with the law and support the principle of the 3Rs to refine, reduce and replace the use of animals in research. PSC Support supports the AMRC Statement on Animal Research. Our expectations for responsible use of animals are set out in the document Responsibility in the use of animals in bioscience research.

Lay Appraisal Criteria Guide

The research grant applications are considered by lay reviewers (usually patients) as well as by scientific experts. Lay reviewers will appraise the application based on the relevance and importance of the proposal and on patient and public involvement and engagement

Patients are involved in appraising research applications because PSC Support places great value on the patient voice.

Relevance of idea or proposal to PSC Support research priorities
How does the proposal relate to our research priorities?
Importance of this research to people with PSC
Does this address an important and valid research question? Refer to PSC Unanswered Questions.
Opinion on patient and public involvement and engagement undertaken so far and proposed during project.

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Application Success Rates

Success rates of eligible applications are as follows:

Year	Letters of Intent Received	Number of Full Applications Invited	Number funded	Success Rate
2015/16	—	3	2	67%
2016/17	—	4	2	50%
2017/18	—	4	3	75%
2018/19	—	1	1	100%
2019/20	—	4	3	75%
2020/21	—	COVID	COVID	0%
2021/22	—	1	1	100%
2022/23	—	1	1	100%
2023/24	—	8	4	50%
2024/25	—	17	8	47%
2025/26	19	9	2	22%

See research we've funded

Unanswered Questions

The following list of questions is taken from responses in our PSC Support patient surveys.

Questions about why people get PSC

What is the cause of PSC?

Can PSC be prevented?

What is PSC doing to me?

Who gets PSC?

Why is there such variability between PSCers?

What environmental factors are involved in PSC?

How are genetics involved in PSC?

Are members of my family likely to have PSC?

Can you screen for PSC?

Questions about curing or halting PSC

Can you cure me?

Can you halt the progression on PSC?

Questions about diagnosis, prognosis and identifying PSC risks

How can PSC be diagnosed early?

Why does PSC return after transplant in some people?

What is my prognosis?

Why does PSC progress quickly in some people?

Will I need a transplant?

Identify warning signals that my PSC will be aggressive.

Identify warning signals that I may get a cancer.

Questions about symptoms

Can you understand/treat my fatigue?

Can you understand/treat my itch?

Can you understand/treat my pain?

Does exercise help fatigue in PSC?

Addressing other symptoms.

Questions about helping ourselves

What can I do to stay healthy?

Should I eat a special diet?

How can I improve my mental health?

Questions about PSC and other diseases

How is PSC linked to Inflammatory Bowel Disease (IBD)?

How is PSC linked to other diseases, especially autoimmune diseases?

What is the best treatment regime for PSC-IBD?

What is the role of surgery in PSC-IBD?

Questions about therapies and interventions

Do antibiotics work in PSC?

Does bacterial therapy work in PSC?

What does ursodeoxycholic acid do?

Does vancomycin help people with PSC and/or PSC-IBD?

Can an existing compound or intervention be repurposed to help people with PSC?

Does manipulating the microbiome help in PSC?

Questions about clinical care

How can I get a doctor that understands PSC?

What should I ask my doctor?

What routine tests should I have?

What is the best way to screen for cancers in PSC and/or PSC-IBD?

How should IBD be managed after liver transplant?

How should acute cholangitis be diagnosed?

How can I recognise acute cholangitis?

Will I need a transplant?

What is the best way to deliver a PSC diagnosis?

What is the best way to talk about cancer to a PSC patient?

Awards

Research should start as soon as possible after the grant is awarded. Ethical approvals, if required, must be in place before the work commences. All licences relating to research using animals must be valid and in place.

PSC Support is a member of the Association of Medical Research Charities. Provided the study meets the NIHR’s definition of a ‘research study’, the selected project(s) will also be eligible for adoption by the UK Clinical Research Network and therefore will be eligible for NIHR support. For clinical research proposals, applicants are encouraged to contact their local NIHR Clinical Research Network for advice as early as possible.

Any queries relating to submission of the application must be referred directly to PSC Support. Applicants or their colleagues may not contact a Scientific Review Committee member or PSC Support Trustee to discuss any aspect of an application or the decision reached on it.

Additional Information

Association of Medical Research Charities Member

We've joined a select group of 150 UK charities that have demonstrated best practice in managing research funding and PSC Support is proud to have been approved as a member of the Association of Medical Research Charities (AMRC). The AMRC is a prestigious membership organisation dedicated to supporting medical research charities in saving and improving lives through research and innovation.

Martine Walmsley, PSC Support Head of Research Strategy, said, "To be an approved AMRC member is a real testament to our long-term commitment to invest in the very best PSC research and something we are incredibly proud to have achieved. All of PSC Support's funds come from donations. It is important that our incredible donors and fundraisers can be confident that the research they are helping to fund is not only high quality, but also part of a clear strategic plan towards developing effective treatments for PSC."

AMRC membership demonstrates that PSC Support delivers high-quality research and is an indicator of the excellent work we do in research governance and standards. All members, whatever their size, work to the same high standards to ensure that every penny invested in research is well spent, funding only the very highest quality projects. Universities, government and funding bodies use AMRC membership as an indicator of quality research funding.

NIHR RDN Non-Commercial Partner

PSC Support is an NIHR (National Institute for Health Research) RDN Research Delivery Network (RDN) Non-commercial Partner. This means the studies that we fund may be eligible to access the NIHR Study Support Service which is provided by the NIHR Research Delivery Network within the NHS, and the wider public health and social care environment, across England. Read the full policy: Eligibility criteria for NIHR Research Delivery Network Support.

In partnership with your local R&D office, we encourage you to involve your regional NIHR Research Delivery Network team in discussions as early as possible when planning your study. This will enable you to fully benefit from the support available through the NIHR Study Support Service. Find out more about the Study Support Service.

If your study involves NHS sites in England you will need to apply for Health Research Authority (HRA) Approval. Guidance on submitting an application for approvals is available on the HRA website.

Research Costing

Research Policies

Code of Conduct (research)

This Code of Conduct applies to all members of the PSC Support Scientific Review Committee (SRC), external reviewers, applicants and staff/volunteers of PSC Support involved in a funding round.

Maintaining confidentiality is essential for safeguarding the exchange of scientific opinions and assessments.
- Details of research applications and related correspondence, and SRC meetings’ papers are strictly confidential and must be kept secure and not disseminated to or discussed with others outside the review process.
- External reviewers and SRC members must agree to treat all details of applications and their outcomes as confidential.
- External reviewers and SRC members must agree not to input content from our confidential funding applications or reviews into, or use, generative AI tools to develop their peer review critiques. Our peer reviewers are selected for their expertise and experience in their field and we value their unique perspectives.
- Applicants can expect that details of their applications will not be disclosed to those outside the review process by PSC Support.
SRC members and external reviewers can expect appraisals of their applications to be treated in confidence by PSC Support. When we inform applicants of the outcome of their applications, we provide feedback based on reviewers’ comments, and may also summarise the conclusion reached by the SRC. Information that might identify the comments of individual reviewers is never revealed.
SRC members and external reviewers will be notified by PSC Support of the final decisions (made by Trustees) of any applications they have reviewed.
Any member of the SRC who declares a conflict of interest (including a current association with an institution applying for a grant) will not participate in that activity, they will not receive the application(s) and will not be present for discussion of the application(s) at the SRC meeting.
Applicants must not make direct contact with members of the SRC about their application and vice versa.

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Patient and Public Involvement and Engagement (PPIE)

PSC Support is committed to embedding the patient voice in research. We strongly encourage applicants to involve patients early in study design. Our dedicated Patient Panel is available to support researchers in this way.

We support the AMRC position statement on the importance of involvement in medical research

If you are a researcher and would like some support involving people affected by PSC in your research, please get in touch with Martine at martine@pscsupport.org.uk

If you have PSC, or someone close to you does, and you'd like to get involved in research, we'd love to hear from you. Please let us know here.

Animal Research

PSC Support follows the AMRC principles in the use of Animals in Research

We support the AMRC statement on animal research.

Use of Animals Policy

PSC Support appreciates that research using animals plays an important role in the research process and we support the principle of using animals when it is necessary

to advance the understanding of primary sclerosing cholangitis and associated conditions.
to develop treatment when there is no alternative that can be used to find out the same information without using animals.

PSC Support will only fund research involving live animals when this is essential to the outcome of the research, there is no alternative method of obtaining the data, and when pain and distress to animals is minimised.

We use expert peer review to ensure that we fund only high quality research where the benefits to human health outweigh any harm to animals. The use of animals must be fully justified in all applications for research grants.

PSC Support requires that all experiments should be carried out with due concern for the welfare of the animals, and using the minimum number necessary to provide clear data in well-designed experiments.

Individuals working on experiments using animals must have a personal licence and the institution must also have an establishment licence.

High standards of animal welfare are important. These both minimise discomfort for the animals involved and enable researchers to get reliable results. We only fund research which complies with the law and support the principle of the 3Rs to refine, reduce and replace the use of animals in research:

Replace the use of animals with alternative techniques, or avoid the use of animals altogether
Refine the way experiments are carried out, to make sure animals suffer as little as possible. This includes better housing and improvements to procedures which minimise pain and suffering and/or improve animal welfare.
Reduce the number of animals used to a minimum by seeking ways to find out information from fewer animals or more information from the same number of animals.

PSC Support accepts that not all of the public can accept research using animals.

Our PSC Support Agreement for grant research awards specifically refer to the ethical use of animals. Our requirements are that:

1.1. A project involving the use of animals may not be commenced in the absence of Home Office licences covering all relevant institutions the researchers and the research activity. Acceptance of an award constitutes confirmation that any necessary consent including Home Office approval under the Animals (Scientific Procedures) Act 1986 or other relevant legislation has been obtained. Grant holders are expected to adopt procedures and techniques which minimise the use of animals.

1.2. Research using animals plays an important role in the research process and PSC SUPPORT supports the principle of using animals when it is necessary to advance the understanding of Primary Sclerosing Cholangitis and associated conditions to develop treatment when there is no alternative that can be used to find out the same information without using animals. Expert peer review is used to ensure that we fund only high quality research where the benefits to human health outweigh any harm to animals. PSC SUPPORT supports the Association of Medical Research Charities statement on animal research.

1.3. All experimental programmes supported by PSC Support must only use animals were there are no alternatives.

1.4. Experiments using animals funded by the PSC Support must:

1.4.1. use the simplest possible, or least sentient, species of animal

1.4.2. ensure that distress and suffering are avoided wherever possible

1.4.3. employ an appropriate design and use the minimum number of animals consistent with ensuring that the scientific objectives will be met

1.5. See the NC3Rs website for further information and guidance.

1.6. All grant holders using animals must implement the principles in the cross-funder guidance Responsibility in the Use of Animals in Bioscience Research.

1.7. Grant holders using non-human primates must comply with the NC3Rs guidelines Primate Accommodation, Care and Use.

1.8. Grant holders should make use of the ARRIVE guidelines when designing their experiments, and ensure that they report animal-based studies in accordance with the ARRIVE guidelines as far as possible, taking into account the specific editorial policies of the journal concerned.

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Generative AI

As a member of the AMRC, PSC Support follows the Research Funders Policy Group joint statement on the use of generative AI tools in funding applications and assessment.

Generative AI tools offer potential benefits for research but also challenges and risks. The joint statement sets consistent standards on generative AI tools in funding applications and assessment across research funding organisations in the UK. It makes clear that AI technology should not be used for peer review and that, if used in other contexts, such as preparing funding applications, it must be clearly cited and acknowledged.

Supporting Research in Universities

PSC Support follows the AMRC Statement on Supporting Research in Universities

As a member of AMRC, PSC Support endorses the principles of the AMRC Statement on Supporting Research in Universities.

Key principles

AMRC charities remain committed to supporting research and the careers of talented researchers in UK universities;
AMRC believes that government is primarily responsible for provision of underpinning funding for the UK biomedical science base;
Where it is within their charitable objects and appropriate for them to do so, AMRC encourages its member charities to contribute towards a sustainable science base in universities through the support of longer-term funding for people and facilities;
Universities should understand the full economic costs of proposed research facilities or activities when seeking financial support from charities;
Charities will not normally meet the full economic costs of the research they are supporting, especially for responsive mode funding calls;
Universities will be expected to contribute resources from QR, including the charity support element, in order to meet the full costs of research in partnership with charities;
Charities will not contribute a percentage overhead towards general university infrastructure;
Charities are unlikely to respond positively to demands to fund research activity on the basis of a fixed percentage of research costs (as is the case for other funders including the Research Councils); and
AMRC will work with member charities, government and universities to develop new models of partnership funding that will enable charities of all sizes to develop their commitment to research in a sustainable way.

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Conflicts of Interest

Got a question?

If you have any questions regarding our funding, please get in touch.

Applicants sometimes contact us to ask informally about the appropriateness of their application and seek advice about our remit. Such enquiries are dealt with by charity staff who are not scientific experts and will only advise if an application isn’t suitable for funding when it is clearly outside our remit. Charity staff will not comment on likelihood of securing funding from PSC Support because all applications must go through the independent peer review process prior to any decisions about funding.