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Our research

PSC Support provides financial grants to high quality, peer-reviewed PSC research

PSC Support was set up over twenty years ago. Supporting and funding research has always been an important part of our work, thanks to your generous donations. We are proud of our grant research programme, which has clearly defined and transparent mechanisms in place, and a robust peer-review process to ensure your donations fund only the highest quality, most worthwhile PSC research. However, we must do more to accelerate this progress. By 2030, we will fund and support more PSC research than ever before, offering over £1 million in grants to researchers as part of our commitment to help find effective treatments for everyone with PSC by 2030.

Cheque presentation

Studies funded by PSC Support:

Dr Nicholas Ilott


Assessing protein levels in the small intestine in people with PSC and ulcerative colitis to understand how the liver and the intestine interact with each other in PSC.

Professor Jesús Bañales and Dr Pedro Rodrigues


Continuing to develop a blood test to detect early bile duct cancer and to predict who is most at risk in people with PSC.

Dr Simon Rushbrook


Continuing to develop a blood test to diagnose PSC. His previous research, funded by PSC Support, found ten promising antibody markers which he will now test on a larger scale to find one that is unique to PSC.

Dr Edward Jarman


Investigating how the cells in people with PSC can develop into bile duct cancer (cholangiocarcinoma).

Dr Palak Trivedi


Investigating the potential of a new treatment (faecal microbiota transplantation) to slow the progression of PSC and improve the quality of life for patients.

Dr Simon Rushbrook and Dr Liz Goode


Developing a diagnostic blood test for people with PSC.

Professor Jesús Bańales


Investigating non-invasive biomarkers in blood to predict PSC prognosis and early cholangiocarcinoma (CCA) development.

Dr Veronica Ranieri


Creating a personalised psychological intervention for primary sclerosing cholangitis: understanding mental health and wellbeing among people with PSC.

Dr Elena Marcus and James Ryan

2018 and 2024

Developing a tool to measure quality of life in people with PSC.

Dr Kate Lynch


Characterising the subtypes and function of liver immune cells in PSC/UC.

Dr Palak Trivedi


The VAPoR Study: Validating the Prognostic Utility of Vascular Adhesion Protein 1 in PSC.

Dr Elizabeth Goode


Identifying the true genes underlying each of the twenty-three known loci associated with risk of developing PSC.

Professor Catherine WIlliamson


Investigating the effect of male cholestasis (i.e. men with PSC) on the epigenome of sperm and the impact on the health of children of men with cholestasis.

Dr Rachel Guest


Developing an unbiased screen for novel clinical and molecular biomarkers of the progression of primary sclerosing cholangitis to biliary tract cancer

Professor Gideon Hirschfield


Developing the West Midlands Virtual PSC Programme

Professor Luke Boulter


Investigating the role of non-canonical Wnt signalling in the establishment of fibrosis during PSC



UK-PSC Project Manager

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