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John Radcliffe Hospital, Oxford

Fully recruited

Take Part in the DYNAMHIX Study

Dr Nick Ilott, Senior Researcher and Lead Bioinformatician for the Oxford Centre for Microbiome Studies, is analysing blood and stool samples over the course of a year in people with PSC.

This will allow us to better understand and measure disease progression and how the liver and gut may influence the microbiome and their impact on the disease.

Study Name DYNAMHIX in PSC: Longitudinal dynamics of the hepatic-intestinal axis in PSC
Recruiting now? No longer recruiting
Participating Centres and Contact Oxford University Hospitals, John Radcliffe hospital.


Liver disease diagnosis Large duct PSC
Age 18+ years
Females: can I be pregnant? Yes
Is IBD allowed? Yes
Is there an ALP (alkaline phosphatase) requirement? No
Can I take UDCA (Urso)? Yes
Can I take part if I have a stent? No
Are recent acute cholangitis (ie bacterial cholangitis) attacks allowed? Yes
Can I take part if I have had a liver transplant? No
Is cirrhosis allowed? No
Previous studies and information DYNAMHIX website
Procedures and tests include: Providing stool samples (at home) and blood samples during your routine clinic appointments
Travel expenses? No unfortunately we cannot cover travel expenses.
How many Study Visits? How long will each Study Visit be? We would like to collect blood and stool samples (home stool kits) every 3 months for 1 year. Samples collected for the study are planned to be taken at clinic appointments and in line with usual care. If appointments happen to be more spread out then we may ask participants if they are willing to visit the hospital to provide samples outside of their clinical appointment.
Duration on study drug (or placebo) 12 months
Basic design of study This is a clinical observational study and as such there is no intervention nor treatment outside of current clinical practise. The study aims to assess how microbial metabolites in the intestine (measured in stool) change over the course of a year in people with PSC and whether these are associated with fluctuations in liver function measurements from blood and/or markers of intestinal inflammation measured in the stool samples.
Sponsor Funded by GutsUK and sponsored by the University of Oxford as a subproject of the TGU GI biobank

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