Research Update: New Clues to PSC Progression
We have a significant update from the PSC Support-funded research project that aims to better predict how PSC progresses.
Researchers are using a cutting-edge technique called spatial transcriptomic analysis to create a highly detailed map of PSC liver tissue, showing which genes are active in specific cells and where they are located. They are analysing 16 liver tissue samples taken over time, including some from people who later developed cholangiocarcinoma (bile duct cancer), which could help identify early warning signs.
Early findings show important differences in the immune environment of PSC compared to other liver conditions. For example, protective Kupffer cells appear better preserved in PSC, while a higher number of potentially damaging cytotoxic CD8 T cells have been observed.
This early research is providing crucial new insight into the unique immune processes of PSC. The goal is that this work will ultimately lead to better methods for detecting progressive disease earlier in the future.
Turning Ambition into Action in 2026:
Our Fortnight in Focus
At PSC Support, we want a world without PSC. We work tirelessly behind the scenes to drive research and improve lives. Here is a snapshot of what we've been up to:
Building Partnerships: We worked with PSC Partners Seeking a Cure to align our efforts for Rare Disease Day, increasing our global impact for PSC patients
Empowering our Community: We confirmed expert speakers for our 2026 Information Day, ensuring our community can hear the latest medical insights directly from PSC specialists.
Empowering our Community: We met with our dedicated community moderators to ensure our online support spaces remain safe, welcoming, and helpful for everyone.
Improving Care: We progressed a major initiative to standardise PSC care across the UK, advocating for every patient to receive high-quality care.
Organisational Excellence: Our new leadership team met to ensure our resources are focused on activities that have the most impact.
Organisational Excellence: We secured charity places in the 2026 Amsterdam Marathon, expanding our international fundraising opportunities to power future research and support.
Empowering our Community: We filled all of our Great North Run places with amazing fundraisers who are committed to raising crucial funds for our small charity!
Progressing Research: We collaborated with European liver disease experts at ERN-RARE-LIVER to plan PSC-focused sessions for an upcoming international rare disease conference.