Research Update: New Clues to PSC Progression
We have a significant update from the PSC Support-funded research project that aims to better predict how PSC progresses.
Researchers are using a cutting-edge technique called spatial transcriptomic analysis to create a highly detailed map of PSC liver tissue, showing which genes are active in specific cells and where they are located. They are analysing 16 liver tissue samples taken over time, including some from people who later developed cholangiocarcinoma (bile duct cancer), which could help identify early warning signs.
Early findings show important differences in the immune environment of PSC compared to other liver conditions. For example, protective Kupffer cells appear better preserved in PSC, while a higher number of potentially damaging cytotoxic CD8 T cells have been observed.
This early research is providing crucial new insight into the unique immune processes of PSC. The goal is that this work will ultimately lead to better methods for detecting progressive disease earlier in the future.
Turning Ambition into Action in 2026:
Our Fortnight in Focus
At PSC Support, we want a world without PSC. We work tirelessly behind the scenes to drive research and improve lives. Here is a snapshot of what we've been up to:
Global Research Preparation: We helped develop patient consent documentation for a global PSC research initiative coming to the UK in 2026 so it aligns with UK patient needs.
Representing the Patient Voice: We provided the patient perspective in a panel interview with a major funder regarding a potential new clinical trial for PSC.
Patient-Led Governance: We convened a Patient Panel to review a plans for a new UK study, ensuring the research focuses on the practical needs and safety concerns of people with PSC.
Global Advocacy: We had a late-night meeting to finalise a joint abstract with PSC Partners Seeking a Cure (USA) to present our shared patient survey data at a major European conference.
Regulator Collaboration: We participated in a national workshop with regulators to identify ways to speed up access to new rare disease treatments.
Scientific Leadership: We received excellent editorial feedback on a new textbook chapter about PSC we've been working on with European Reference Network for Rare Liver Diseases experts to improve clinical knowledge of PSC.
Research Governance: We initiated a project to update our research governance protocols and migrate historical research data into our new Grant Management System, ensuring all the research we fund is accurately recorded.
Supporting our Fundraisers: We simplified the process for applying for a Great North Run this year, making it easier for fundraisers and more efficient for PSC Support - win/win!