Progress Update: Characterising Genetic Changes in Bile Ducts
Progress Update: Characterising Genetic Changes in Bile Ducts
Dr James Sun
We are pleased to share a significant update on the PSC Support-funded research project, 'Characterising genetic changes in bile ducts.' This work is a crucial step in fulfilling our goal to Unlock Understanding of Primary Sclerosing Cholangitis (PSC) by investigating the fundamental biological processes that cause the disease.
The research team has made excellent progress in setting up the foundational elements required for the study's core analysis:
- Sample Collection Complete: We are grateful to the PSC patients who agree to let researchers take samples for research purposes.
- 3D Model System Established: The complex three-dimensional (3D) model system, which will be essential for investigating how genetic changes affect bile duct cells, has been successfully set up and validated by the team.
- Critical Analysis Underway: The project is now moving into the key analytical phase. The team is currently working to conduct DNA sequencing to detect the precise genetic changes being investigated. The researchers are carefully assessing the most effective technique to use to ensure the data is meaningful and robust, reflecting a measured and scientific approach.
This work is part of our commitment to accelerating research to find the breakthroughs people with PSC so desperately need. If you have donated or fundraised for PSC. Thank you. These projects are only possible because of you.
Turning Ambition into Action in 2026:
Our Fortnight in Focus
At PSC Support, we want a world without PSC. We work tirelessly behind the scenes to drive research and improve lives. Here is a snapshot of what we've been up to:
Building Partnerships: We worked with PSC Partners Seeking a Cure to align our efforts for Rare Disease Day, increasing our global impact for PSC patients
Empowering our Community: We confirmed expert speakers for our 2026 Information Day, ensuring our community can hear the latest medical insights directly from PSC specialists.
Empowering our Community: We met with our dedicated community moderators to ensure our online support spaces remain safe, welcoming, and helpful for everyone.
Improving Care: We progressed a major initiative to standardise PSC care across the UK, advocating for every patient to receive high-quality care.
Organisational Excellence: Our new leadership team met to ensure our resources are focused on activities that have the most impact.
Organisational Excellence: We secured charity places in the 2026 Amsterdam Marathon, expanding our international fundraising opportunities to power future research and support.
Empowering our Community: We filled all of our Great North Run places with amazing fundraisers who are committed to raising crucial funds for our small charity!
Progressing Research: We collaborated with European liver disease experts at ERN-RARE-LIVER to plan PSC-focused sessions for an upcoming international rare disease conference.