What liver research gap did this study address?

Primary sclerosing cholangitis (PSC) is a chronic liver disease that damages and narrows the bile ducts, which carry bile from the liver to the small intestine. The bile helps the digestion of food in the gut, it’s reused by the body but part of it comes out with the stools. In advanced PSC, liver transplantation is currently the only treatment. However, PSC can sometimes return in the transplanted liver, known as recurrent PSC (rPSC).

Previous studies reported different frequencies for recurrence and suggested several factors that may be associated with rPSC. This study brought together the available evidence from around the world to help us understand better how often PSC recurs after liver transplantation and also to identify factors associated with recurrence.