Research Update: New Clues to PSC Progression
We have a significant update from the PSC Support-funded research project that aims to better predict how PSC progresses.
Researchers are using a cutting-edge technique called spatial transcriptomic analysis to create a highly detailed map of PSC liver tissue, showing which genes are active in specific cells and where they are located. They are analysing 16 liver tissue samples taken over time, including some from people who later developed cholangiocarcinoma (bile duct cancer), which could help identify early warning signs.
Early findings show important differences in the immune environment of PSC compared to other liver conditions. For example, protective Kupffer cells appear better preserved in PSC, while a higher number of potentially damaging cytotoxic CD8 T cells have been observed.
This early research is providing crucial new insight into the unique immune processes of PSC. The goal is that this work will ultimately lead to better methods for detecting progressive disease earlier in the future.
Turning Ambition into Action in 2026:
Our Fortnight in Focus
At PSC Support, we want a world without PSC. We work tirelessly behind the scenes to drive research and improve lives. Here is a snapshot of what we've been up to:
Organisational excellence: We simplified our personal data consent process and streamlined how we record patient stories to ensure that the lived experiences of our community are captured accurately and securely to inform future work.
Progressing Research: We coordinated a series of upcoming meetings with international researchers and pharmaceutical companies, which supports better informed decisions for people with PSC, research, or care. This groundwork helps keep PSC research focused on the primary needs of the patient community.
Progressing Research: We reviewed and contributed to scientific abstracts and posters for the upcoming EASL international liver congress, which strengthens the quality of future research for people with PSC, research, or care.
Progressing Research: We engaged with the MHRA to prepare for the upcoming national consultation on rare disease therapies, representing PSC patients in the wider community. Maintaining this direct dialogue ensures our organisation is prepared to respond formally and protect the interests of those living with PSC
Improving Care: We presented about what it is really like to live with PSC to gastroenterologists This first-hand insight equips healthcare professionals to better understand the day-to-day challenges of PSC.
Income Generation: We secured a place in the prestigious Big Give Small Charity Week match-funding campaign, so that we can maximise future donations from our supporters as every donation between 22 and 29 June will be doubled!
Progressing Research: We recruiting for a research and advocacy officer to expand our core team. This additional capacity ensures we can better support scientific studies and represent the patient voice at every level.