Research Update: New Clues to PSC Progression
We have a significant update from the PSC Support-funded research project that aims to better predict how PSC progresses.
Researchers are using a cutting-edge technique called spatial transcriptomic analysis to create a highly detailed map of PSC liver tissue, showing which genes are active in specific cells and where they are located. They are analysing 16 liver tissue samples taken over time, including some from people who later developed cholangiocarcinoma (bile duct cancer), which could help identify early warning signs.
Early findings show important differences in the immune environment of PSC compared to other liver conditions. For example, protective Kupffer cells appear better preserved in PSC, while a higher number of potentially damaging cytotoxic CD8 T cells have been observed.
This early research is providing crucial new insight into the unique immune processes of PSC. The goal is that this work will ultimately lead to better methods for detecting progressive disease earlier in the future.
Turning Ambition into Action in 2026:
Our Fortnight in Focus
At PSC Support, we want a world without PSC. We work tirelessly behind the scenes to drive research and improve lives. Here is a snapshot of what we've been up to:
Building Partnerships: We contributed a comprehensive chapter to a new medical textbook for nurses and allied health professionals, ensuring that the patient perspective is integrated into clinical education.
Building Partnerships: We participated in a planning meeting for the update of national clinical guidelines for PSC.
Building Partnerships: We prepared strategic questions for an upcoming international forum titled “Putting Patients First: From Research to Treatment.”
Organisational Excellence: We updated our web details to make it less likely information from us sent by email ends up in your spam folders.
Progressing Research: We are collaborating with European partners to develop a simplified research registry for pregnancy outcomes, building the evidence base needed to improve medical guidance for women with PSC.
Progressing Research: We completed a formal submission to the Scottish Medicines Consortium to advocate for the value of a potential new treatment for PSC patients.
Progressing Research: We reviewed the participant information for a new academic clinical trial to ensure it is clear and accessible for patients.