Take Part in a Clinical Trial
Well-designed clinical trials are the best chance we have of finding effective medicines for PSC. We believe that people with PSC should be fully informed about how clinical trials work, what’s involved and why they’re so important.
Where do I begin?
- Check our map and list below to find trials that are recruiting patients and see if you are suitable.
- Sign up to PSC Support research bulletins to learn about new PSC trials.
- Join the UK-PSC Registry to build our knowledge of PSC.
- Got a question? Our Clinical Trials Guide has lots of information about how to join clinical trials and what's involved.
- Learn about the latest PSC research.
"PSC already takes so much away from us. Usually we are having to react to changing symptoms or worsening of the condition, but by signing up for a clinical trial, we are taking back some of that control." Gareth, clinical trial participant.
Clinical trials map
Updated frequently
The map below shows which hospitals are recruiting for the clinical trials. Click on the box in the top left-hand corner of the map to look at all trials or individual trials.
NOTE THAT RECRUITMENT AT ANY OF THE SITES MAY BE TEMPORARILY HALTED AT ANY TIME BECAUSE OF COVID-19. WE MAY NOT UPDATE IMMEDIATELY BECAUSE, QUITE RIGHTLY, STAFF IN THE HOSPITALS WILL BE OTHERWISE ENGAGED.
Learn about the latest clinical trials information by signing up to our Research Bulletins.
Find out about the UK-PSC registry, its latest research and how you can join. When you join, you help to build knowledge about PSC.
- Am I eligible (suitable) to take part in a clinical trial?
- Will my doctor contact me about clinical trials?
- My hospital is not running the clinical trial I want to take part in. What should I do?
- Why do I need to sign a consent form?
- What questions should I ask?
- What is a study visit?
- Can I choose the days I attend?
For answers to these questions and more, download our free guide:
This talk was originally broadcast live onto Facebook. We've split it into shorter videos. You can find the whole series on YouTube.
Recruiting now
New study to understand life after transplantation. Complete online surveys.
UK Clinical Study Register number: ISRCTN12358813
Recruiting at 46 hospitals across the UK with come coming
Clinicaltrials.gov Study Register: NCT06864195
ClinicalTrials.gov Identifier: NCT06286709
Paternally Inherited Phenotypes in Cholestasis Study - (PIP-C)
ClinicalTrials.gov Identifier: NCT03337074
This study is investigating whether cholestatic liver diseases such as PSC can impact the structure and function of sperm. This is important because changes to the sperm can affect the health of the children conceived from those sperm. In this study, the health of 16 – 25 year-old children of fathers with cholestatic liver diseases such as PSC is also being investigated.
The study has 2 arms, the Sperm Epigenome arm and the Outcomes arm. Each participant can decide if they are eligible/would like to take part in one or in both arms of the study.
In the Sperm Epigenome arm, the structure and function of sperm from men with PSC and other cholestatic liver disorders will be investigated and compared to the structure and function of sperm from healthy men.
In the Outcomes arm, basic health parameters in fathers who had PSC or another cholestatic liver disease either before or after their child was conceived will be investigated, as well as basic health parameters in their child when they are aged between 16 and 25 years old.
UK Locations
- King's College Hospital, London
Contact information
Chief Investigator: Professor Catherine Williamson
Not recruiting
Recruitment closed.
Recruitment closed
VISTAS
ClinicalTrials.gov Identifier: NCT04663308
The VISTAS Study is seeking patients diagnosed with PSC to evaluate whether the investigational drug volixibat is a safe and effective treatment option for cholestatic itch.
ORBCEL-C™
This study is investigating the safety and activity of the use of ORBCEL-C™ in the treatment of patients with primary sclerosing cholangitis, rheumatoid arthritis, lupus nephritis and Crohn’s disease.
ClinicalTrials.gov Identifier: NCT05525520
The PACIFIC Study is seeking adults diagnosed with PSC or PBC to evaluate the investigational drug for cholestatic itch.
ClinicalTrials.gov Identifier: NCT05627362
The ELMWOOD Study is seeking adults diagnosed with PSC to evaluate the safety and efficacy of Elafibranor.
The Liver Unit at University Hospitals Birmingham (Queen Elizabeth Hospital) is leading this study.
PLN-74809
ClinicalTrials.gov Identifier: NCT04480840
This study is investigating the safety, tolerability, and pharmacokinetics of PLN-74809 in patients with PSC.
Selected mesenchymal stromal cells to reduce liver inflammation
ISRCTN Identifier: ISRCTN73586959
The aim of this study is to investigate whether patients with primary sclerosing cholangitis (PSC) or autoimmune hepatitis (AIH) can be safely and effectively treated with a therapy called mesenchymal stromal cells (MSC). This study is also referred to as the 'MERLIN' trial.
Fully recruited.
Fully recruited
This study is fully recruited.
MuM-PreDiCT is a study about care during pregnancy, birth and after birth.
NorUrsodeoxycholic Acid in the Treatment of PSC
EudraCT Number: 2016-003367-19
The aim of this study is to compare norursodeoxycholic acid (NorUrso, NorUDCA) with placebo in the treatment of primary sclerosing cholangitis.
NOW FULLY RECRUITED IN THE UK (June 2022)
Online study recruiting now.
Compensation provided for time spent sharing your experience with cholestatic pruritus (itch associated with liver disease)
Vancomycin
ClinicalTrials.gov Identifier: NCT05376228
This study is investigating vancomycin in PSC. It has now recruited all participants into the trial.
Rest of world
Rest of World
We've searched ClinicalTrials.gov for privately and publicly funded clinical studies across the globe.